Poof! solution
by Kegler

As indicated by 27 Across, THE LADY VANISHES (a movie directed by 4 Down, ALFRED HITCHCOCK),
twenty-three answers have a lady's name “vanish” before entry.  Each of the twenty-three names is shown in red.

Poof! solution grid

Across
1PO + ME + GRAN + ATE
6POI (1st letters)
9TRUTHFUL (HURL TUFT anag)
12DEVIL (rev)
14B + LAB
15C + HATE + LA(I)NES
17OF + F
18IN + FAMi + lY
19L + ID
20POUR (hidden)
21RE(A + SON)ED
22T(HE(I)'D)IOT (TO IT rev)
24EEL (even letters)
25BI(R)D
27THE LADY VANISHES
28ELDER (2 defs)
29S + CREW
31SERT (TRES rev)
32H(ERNIe)A
36HAVEn
38CAT(AMA + RAN)S
40POIGNANCY (COP ANY GIN anag)
41A + MAR + YLLIS (rev)
42C(RED)O
43SU + TRA (rev)
44ITHACA (hidden)
45GREBE (rev. hidden)
46DISENFRANCHISED (DANCERS FINISHED anag)
49I DO + L
52HIRSUTE ("HER SUIT" hom)
54shELVES
55CA(LO)RIES
56R(A)ILED
57SEALS + KIN
58NOW AND AGAIN (DANA IN A GOWN anag)
Down
1PROP + ELL + ENT (TEN anag)
2REF(UT)ED (DEFER rev)
3EVENING (2 defs)
4ALFRED HITCHCOCK
5ELI (hidden)
6PAL(I)S + ADE
7OBTAIN (IN BOAT anag)
8ICE(SKATE)R (CAKE TIERS anag)
9THE + O
10FAINTHEARTED (hidden)
11pUTTERER
13V(I)RILE (LIVER anag)
14BLINDALLEYS (SELL BADLY IN anag)
16SI + DE + STEP (rev)
23EA + R + NEST + NESS
25BARC + A + ROLE (CRAB rev)
26DIRENESS (SENDER IS anag)
27TE(A + CA)DDIES
30P + OLLYWOGS (SLOWLY GO anag)
32H + ALL
33ENLIST (TINSEL anag)
34S + P(ECIM)EN (MICE rev)
35RIO DE JANEIRO (ON RADIO I JEER anag)
36H + OUR
37VERBOTEN (BENT OVER anag)
39BRAHMA (rev. hidden)
47ISLE ("AISLE" hom)
48D + RAG
50LE MON(A)DE
51RE(TIN)AL (NIT rev)
53ANNUL + I