Never Give Up solution
by Kegler

As indicated by 30 Across, FIGHT TO THE FINISH, eleven synonyms for “fight” have been moved to the ends of their entries.

Never Give Up solution grid

Across
2P(RUN)ING
7LON(G)'S + HOT
14L(ABE) L
15BOUTIQUE ("BOO TEAK" hom)
17OVALS (SALVO anag)
18ROPE (hidden)
20IOTA (A TO I rev)
21S(I)TES (SETS rev)
23SKYSCRAPER (CRASS PERKY anag)
24SCORPIONS (IN CROPS SO anag)
25BALL + OT (TO rev)
27D(OG + S)HOW (GO rev)
30FIGHT TO THE FINISH
32Y + OGA (rev)
34FARSEEING (REF EASING anag)
37S(WART)HIER
39D&R + YROT (rev)
41FEUDALISM (USED A FILM anag)
43OUsT
44RATE + L
45E + NSURE (NURSE anag)
46O(UT)RANGE
47CAME + LEER
48SET-TOP BOX ("BET TOP SOX" spoonerism)
49OYSTER (hidden)
Down
1C + LASS + IF + Y
2PA(TRIO)T + IC
3RE + VERB
4SP(ATU)LA (rev)
5NILE (LINE anag)
6IQS (1st letters)
8hOBOES
9GUEST ("GUESSED" hom)
10STICKS (2 defs)
11HERO WORSHIP (WHO PERISH OR anag)
12OCT + AVOnS
13TRA + PS (rev)
16UNKNOTS (rev. hidden)
19PR(O)OF
22TO(N)G
23SOLO (rev. hidden)
26THE + R,M
27DEF + RAYED (FED rev)
28GI + N + RUM + MY
29WHIT(TL)ER (LT rev)
31H + AIR
33G(H)ET TO
35ARLENE (LEANER anag)
36COULEE ("COOLIE" hom)
37ST(R)OP
38A + S + SET
39DEER ("DEAR" hom)
40D(A)UB
41dALAS (rev)
42DOES (2 defs)